79 Research = 30%-80% Reduction in Medical R&D Timelines, per Insilico Medicine & Cradle Note: Pre-Clinical Candidate Status marks the point at which a lead molecule (or biologic) has satisfied all discovery-stage gates and is officially handed off to the development organization for work related to beginning human clinical trials. Figures collected from 2021-2024. Source: Cradle, Insilico Medicine via BioPharmaTrend, ‘Insilico Medicine Reports Benchmarks for its AI-Designed Therapeutics’ (2/25) AI-Driven Drug Discovery – 2021-2024, Per Insilico Medicine, Cradle & BioPharmaTrend Months to Pre-Clinical Candidate Status Education / Government / Research AI Adoption = Rising Priority Pharma companies that use Cradle are seeing a 1.5x to 12x speedup in pre-clinical research and development by using our GenAI platform to engineer biologics. - Stef van Grieken, Co-Founder & CEO of Cradle, 5/25 Months to Reach Pre-Clinical Candidate Status 0 25 50 Solid Tumors (QPCTL) Inflammatory Bowel Disease (PHD1/2) Idiopathic Pulmonary Fibrosis (TNIK) Traditional Approaches Traditional approaches can take 2.5-4 years